WebJul 25, 2012 · Multiple covalent modifications on a histone tail are often recognized by linked histone reader modules. UHRF1 [ubiquitin-like, containing plant homeodomain (PHD) and really interesting new gene (RING) finger domains 1], an essential factor for maintenance of DNA methylation, contains linked two-histone reader modules, a … WebPKA was eluted from DEAE- cellulose column with a linear NaCl gradient. Two types of PKA, Type I (eluted at low ionic strength) and Type II (eluted at high ionic strength), were collected, and their activities were determined based on the rate of incorporation of [γ-32 P]-ATP into histone. Under physiological conditions, Type I PKA activities ...
项目文章 组蛋白磷酸化介导肝脏胰高血糖-PKA-CREB的糖异生程 …
WebHowever, the mechanisms that regulate histone-modifying enzymes are largely unknown. Here, we characterized a protein kinase A (PKA)-dependent histone lysine demethylase complex, PHF2-ARID5B. PHF2, a jmjC demethylase, is enzymatically inactive by itself, but becomes an active H3K9Me2 demethylase through PKA-mediated phosphorylation. WebApr 6, 2024 · The glucagon-PKA signal is generally believed to control hepatic gluconeogenesis via the CREB transcription factor. Here we uncovered a distinct function of this signal in directly stimulating histone phosphorylation for gluconeogenic gene regulation in … lights to mount on wall
项目文章 组蛋白磷酸化介导肝脏胰高血糖-PKA-CREB的糖异生程 …
WebOct 14, 2011 · Protein Kinase A (PKA) Protein Phosphorylation Histone H1 Introduction Eukaryotic DNA wrapped by core histones H2A/H2B/H3/H4 to form nucleosomes is further packed by linker histone H1. Ten H1 subtypes exist in human ( 1 ). Among them, H1.4 is one of the most abundant isoforms. WebSep 27, 2024 · PKA is a tetrameric holoenzyme, which is composed of a regulatory subunit Bcy1 dimer and two catalytic subunits encoded by TPK1, TPK2 and TPK3. The glycolytic metabolite, fructose-1,6-biphosphate... WebFeb 9, 2024 · Histone H3K4me3 modification is a transgenerational epigenetic signal for lipid metabolism in Caenorhabditis elegans Qin-Li Wan, Xiao Meng, Chongyang Wang, Wenyu Dai, Zhenhuan Luo, Zhinan Yin,... lights to hang up