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WebMechanisms underlying pruritus. Itch, like pain, can originate anywhere along the neural itch pathway, from the central nervous system (brain and spinal cord) to the peripheral nervous system and the skin.. Mechanisms underlying pruritus are complex. The itch signal is transmitted mainly through small, itch-selective C-fibres in the skin in addition to … WebLess common symptoms. Other symptoms of heart failure can include: a persistent cough, which may be worse at night. wheezing. a bloated tummy. loss of appetite. weight gain or … WebIn addition to congestive heart failure, the differential diagnosis of edema should include venous insufficiency, which is the most common cause of lower extremity edema. Venous insufficiency also creates a symmetrical edema, but it may be associated with additional features, including varicose veins, leg discomfort, nonhealing ulcers, and … marathi unicode converter