WebMar 10, 2024 · Connective tissue growth factor (CTGF), also known as CCN2, is a member of the CCN protein family of secreted proteins with roles in diverse biological processes. … WebMay 25, 2024 · Introduction. Connective tissue growth factor (CTGF, CCN2), a cysteine-rich matricellular protein, is an important profibrotic mediator in several fibrotic disorders, including idiopathic pulmonary …
ERK1/2 directly acts on CTGF/CCN2 expression to mediate …
WebConnective tissue growth factor (CTGF) is a cysteine-rich protein induced by transforming growth factor beta (TGF- beta) in connective tissue cells. CTGF can trigger many of the cellular processes underlying fibrosis, such as cell proliferation, adhesion, migration and the synthesis of extracellular matrix; however, its role in acute and ... WebOct 21, 2010 · Connective tissue growth factor (CTGF, also known as CCN2 [Cyr61/CTGF/NOV]) is a profibrotic growth factor that induces proliferation of vascular smooth muscle cells and accumulation of extracellular matrix by inducing collagen production and inhibiting matrix breakdown. 5 CTGF expression is elevated in … cypd fbo
Connective Tissue Growth Factor - an overview - ScienceDirect
WebApr 30, 2016 · ERK1/2 acts on connective tissue growth factor (CTGF/CCN2) expression to mediate the myocardial fibrosis and left ventricular dysfunction. Studies in vivo demonstrate that inhibiting CTGF/CCN2 using a specific antibody decreases myocardial fibrosis and improves the left ventricular dysfunction. Together, these findings show that … WebJul 1, 2007 · Bibliography. Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. WebSep 10, 2008 · Biology of connective tissue growth factor: regulated growth factor and matricellular coordinator. Connective tissue growth factor (CTGF), also know as CCN2, is a small cyteine-rich secreted multi-modular protein, and the founder member of the CCN (cyr61, ctgf, nov) family of immediate-early genes [].CTGF contains four conserved … bim overlay to the riba plan of work